The work was commissioned to Perugino for the monastery of the Poor Clares nuns of Sant’Agnese monastery, a cloistered community still active in Perugia, in the district of Porta Sant’Angelo.

The Virgin, standing before a typically Umbrian landscape, opens her arms in the act of blessing; just above her head two angels are floating in the air, while two small figures at her feet probably represent the two patrons of the fresco, dressed in a Franciscan robe. There are various hypotheses regarding the identity of the patrons: in fact, there is an inscription at the bottom of the painting that seems to bear the names of Sister Euphrasia and Sister Eustochia, but the heavy repaintings suffered by the fresco over the past two centuries made it difficult to read.

 

The work is preserved at the Monastery of Sant’Agnese in Perugia.