The dating is uncertain, but since the twentieth century, when it has been seen for the first time by critics on the occasion of the “Mostra d’Antica Arte Umbra” of 1907, is associated, in the composition, to the Healing of the daughter of Giovanni Antonio Petrazio da Rieti, subject of one of the San Bernardino tablets.

Within an airy and refined environment, whose perspective is punctuated by the geometric-patterned floor, the Virgin is caught in the act of reading a book, now on the ground, when the Archangel Gabriel appears, announcing the Emmanuel. The background, set according to a perspective that Leonardo calls “aerial”, is the product of a careful representation of reality.